Table 4.
Biomarkers of direct and oxidative damage to the DNA.
| Direct DNA damage without Fpg enzyme | Total DNA damage direct and oxidative with Fpg enzyme | Oxidative DNA damage Fpg sites (enz-buff) | Urinary oxidized nucleic acid bases | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tail DNA % | TM (AU) | TL (μm) | Tail DNA % enz | TM enz | TL enz | Tail DNA % | TM | TL | 8oxoGua (μg/g cr) | 8-oxoGuo (μg/g cr) | 8-oxodGuo (μg/g cr) | |
| Mean | 17.68 | 5.67 | 26.85 | 22.39 | 7.87 | 37.40 | 4.71 | 2.20 | 10.55 | 11.21 | 16.13 | 5.53 |
| Median | 16.30 | 5.68 | 27.50 | 22.70 | 7.93 | 39.00 | 4.30 | 2.03 | 10.20 | 6.20 | 14.72 | 5.59 |
| SD | 4.35 | 1.76 | 7.05 | 4.39 | 1.48 | 7.12 | 3.07 | 0.95 | 5.16 | 13.69 | 6.12 | 1.90 |
| 5th perc | 12.42 | 3.34 | 18.51 | 15.68 | 5.51 | 25.68 | 0.48 | 1.08 | 4.93 | 0.01 | 10.04 | 3.28 |
| 25th perc | 15.30 | 4.22 | 20.71 | 18.90 | 7.60 | 33.30 | 2.10 | 1.53 | 5.70 | 0.83 | 11.20 | 4.05 |
| 75th perc | 20.90 | 7.23 | 29.80 | 24.43 | 8.60 | 40.60 | 6.50 | 2.66 | 12.90 | 14.84 | 18.33 | 5.98 |
| 95th perc | 24.42 | 8.09 | 35.76 | 28.60 | 9.83 | 44.96 | 9.6 | 3.70 | 19.55 | 32.53 | 28.30 | 8.17 |
| Max | 26.50 | 8.32 | 44.00 | 31.40 | 10.35 | 54.00 | 11.60 | 4.09 | 20.30 | 46.63 | 31.16 | 10.71 |
| Min | 10.50 | 2.94 | 14.80 | 15.60 | 5.17 | 24.40 | 0.40 | 0.58 | 3.69 | 0.01 | 9.94 | 2.99 |
AU, arbitrary units.