Figure 4.

LHPP expression levels negatively correlated with cell cycle and metastasis in HCC tissues. (a) Analysis of the RNA-seq data of HCC patients from TCGA, and then divide into LHPP low expression and LHPP high expression group, followed using GSEA analysis. (b-f) GSEA analysis showed that pathways including cell cycle, mitotic spindle, G2 M checkpoint, metastasis and liver cancer metastasis were highly enriched in HCC patients with LHPP low expression. (g-h) The metabolic pathways such as oxidative phosphorylation and fatty acid metabolism were remarkably enriched in the LHPP high expression group.