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. 2020 Jun 24;19(14):1846–1854. doi: 10.1080/15384101.2020.1783472

Figure 5.

Figure 5.

LHPP decreases the expression of CCNB1, PKM2, MMP7, and MMP9 in the HCC cells. (a-b) Overexpression of LHPP in the Huh7 and LM3 cells decreased CCNB1, PKM2, MMP7, and MMP9 mRNA levels. CCNB1, PKM2, MMP7, and MMP9 mRNA level was measured using the Real-time PCR. Means±SD from three independent experiments were presented as relative ratios to the control whose value was taken as 1.0. Significant differences were determined using the Student t-test, **P < 0.01, ***P < 0.001. (c-f) A negative correlation was found between the levels of CCNB1, PKM2, MMP7 and MMP9 with LHPP in the HCC tissues. The HCC tissue date comes from the TCGA database.