Table I.
The 30 most significantly up- and downregulated genes in EBV-transformed BLCL samples (S1_B and S2_B), as compared with normal B cell samples (S1_A and S2_A).
| Gene symbol | Upregulated genes Description | Mean Log FC | Gene symbol | Downregulated genes Description | Mean LogFC |
|---|---|---|---|---|---|
| TYROBP | TYRO protein tyrosine kinase-binding protein | 1,429.88 | EBI3 | Epstein-Barr virus-induced gene 3 | -385.97 |
| CX3CR1 | CX3C chemokine receptor 1 | 1,177.16 | MIR155HG | MIR155 Host Gene | -263.21 |
| HBA2 | Hemoglobin subunit alpha | 1,114.79 | LAMP3 | Lysosome-associated membrane glycoprotein 3 | -210.37 |
| S100A9 | Protein S100-A9 | 912.38 | lnc-EFR3B-4 | EFR3 Homolog B, binding | -161.03 |
| CD8A | T-cell surface glycoprotein CD8 alpha chain | 707.23 | CD70 | CD70 antigen | -124.01 |
| CSF1R | Macrophage colony-stimulating factor 1 receptor | 652.57 | PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial | -119.83 |
| CSF1R | Colony stimulating factor 1 receptor | 625.56 | HMMR | Hyaluronan mediated motility receptor | -100.36 |
| GNLY | Granulysin | 548.88 | VWCE | von Willebrand factor C and EGF domain-containing protein | -87.10 |
| S100A10 | Protein S100-A10 | 485.02 | UBE2C | Ubiquitin-conjugating enzyme E2 C | -80.61 |
| CD3D | T-cell surface glycoprotein CD3 delta chain | 477.29 | PHLDA3 | Pleckstrin homology-like domain family A member 3 | -80.53 |
| FOS | Proto-oncogene c-Fos | 462.16 | PIK3CD-AS2 | PIK3CD Antisense RNA 2 | -80.32 |
| CD14 | Monocyte differentiation antigen CD14 | 433.84 | CDCA2 | Cell division cycle-associated protein 2 | -75.40 |
| SERPINA1 | serpin family A member 1 | 423.99 | FSCN1 | Fascin | -72.29 |
| MAFB | Transcription factor MafB | 410.38 | MELK | Maternal embryonic leucine zipper kinase | -68.64 |
| NKG7 | Protein NKG7 | 393.96 | CENPM | Centromere protein M | -67.54 |
| PRAM1 | PRAME family member 1 | 334.75 | PLEKHH3 | Pleckstrin homology domain-containing family H member 3 | -65.46 |
| LILRB3 | Leukocyte immunoglobulin-like receptor subfamily B member 3 | 309.86 | CCNB2 | G2/mitotic-specific cyclin-B2 | -63.19 |
| PTGDS | Prostaglandin-H2 D-isomerase | 305.56 | TYMS | Thymidylate synthase | -61.40 |
| SPOCK2 | Testican-2 | 291.96 | CDK1 | Cyclin-dependent kinase 1 | -59.03 |
| CD2 | T-cell surface antigen CD2 | 283.29 | MND1 | Meiotic nuclear divisions 1 | -54.32 |
| DUSP6 | Dual specificity protein phosphatase 6 | 281.45 | CDCA3 | Cell division cycle-associated protein 3 | -53.49 |
| F13A1 | Coagulation factor XIII A chain | 270.72 | lnc-SPAG1-3 | lincRNA | -49.32 |
| CSF3R | Granulocyte colony-stimulating factor receptor | 226.40 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | -49.25 |
| GP1BB | Platelet glycoprotein Ib beta chain | 214.81 | ASPM | abnormal spindle microtubule assembly | -47.99 |
| CTSW | Cathepsin W | 190.24 | CDCA5 | cell division cycle associated 5 | -47.78 |
| C1orf162 | Transmembrane protein C1orf162 | 173.42 | TROAP | Trophinin-associated protein | -45.83 |
| NRGN | Neurogranin | 172.89 | TPX2 | Targeting protein for Xklp2 | -45.54 |
| LST1 | Leukocyte-specific transcript 1 protein | 157.63 | LOC283710 | Uncharacterized LOC283710 | -42.64 |
| GLIPR2 | Golgi-associated plant pathogenesis-related protein 1 | 143.79 | C16orf59 | Chromosome 16 open reading frame 59 | -41.83 |
| DUSP1 | Dual specificity protein phosphatase 1 | 137.27 | CDC45 | Cell division control protein 45 homolog | -39.36 |