Table II.
Top 3 pathways and gene lists of enriched GO categories, and KEGG pathways of 30 upregulated genes.
| A, Biological process | ||||
|---|---|---|---|---|
| Pathways | GO term | Gene count | Gene lists | P-value |
| Immune system process | GO:0002376 | 18 | TYROBP, GNLY, FOS, CD14, MAFB, CSF1R, CD8A, SERPINA1, LILRB3, CSF3R, S100A9, PRAM1, CTSW, CD3D, CD2, LST1, CX3CR1, DUSP1 | 7.31533E-06 |
| Regulation of immune system process | GO:0002682 | 14 | TYROBP, FOS, CD14, MAFB, CD8A, LILRB3, CSF3R, S100A9, PRAM1, CD3D, CD2, LST1, CX3CR1, DUSP1 | 8.96541E-06 |
| Cell activation | GO:0001775 | 12 | TYROBP, CD14, MAFB, CD8A, SERPINA1, LILRB3, S100A9, PRAM1, GP1BB CD3D, CD2, LST1 | 0.00026598 |
| B, Molecular function | ||||
| Pathways | GO term | Gene count | Gene lists | P-value |
| Signaling receptor activity | GO:0038023 | 9 | CD14, CSF1R, CD8A, LILRB3, CSF3R, GP1BB, CD3D, CD2, CX3CR1 | 0.01814678 |
| Molecular transducer activity | GO:0060089 | 9 | CD14, CSF1R, CD8A, LILRB3, CSF3R, GP1BB, CD3D, CD2, CX3CR1 | 0.02401768 |
| MAP kinase tyrosine/ serine/threonine phosphatase activity | GO:0017017 | 2 | DUSP6, DUSP1 | 0.03972376 |
| C, Cellular component | ||||
| Pathways | GO term | Gene count | Gene lists | P-value |
| External side of plasma membrane | GO:0009897 | 6 | CD14, CD8A, CSF3R, CD3D, CD2, CX3CR1 | 0.00348039 |
| Cytoplasmic vesicle part | GO:0044433 | 10 | TYROBP, GNLY, CD14, F13A1, SERPINA1, LILRB3, S100A9, CTSW, NRGN, CD3D | 0.00526305 |
| Cell surface | GO:0009986 | 8 | TYROBP, CD14, CSF1R, CD8A, CSF3R, CD3D, CD2, CX3CR1 | 0.00549100 |
| D, KEGG pathway | ||||
| Pathways | GO term | Gene count | Gene lists | P-value |
| Hematopoietic cell lineage | KEGG:04640 | 7 | CD14, CSF1R, CD8A, CSF3R, GP1BB, CD3D, CD2 | 5.73E-08 |
| Osteoclast differentiation | KEGG:04380 | 4 | TYROBP, FOS, CSF1R, LILRB3 | 0.01092597 |
| Acute myeloid leukemia | KEGG:05221 | 3 | CD14, CSF1R, DUSP6 | 0.02843111 |