FIG 2.

Timeline for the development of genetic tests and classification methods. (A) Reclassified variants by year, shown as a proportion of reclassified variants by gene group. (B) Timeline of changes in genetic test offering and advances in the reclassification program. (C) Reclassified variants by year, shown as a proportion of all variants identified in each year. ACMG, American College of Medical Genetics and Genomics; FAP/AFAP/MAP, familial adenomatous polyposis/attenuated familial adenomatous polyposis/MUTYH-associated polyposis syndrome; HBOC, hereditary breast and ovarian cancer; MCO, mutation co-occurrence; MCS, melanoma-pancreatic cancer syndrome; PT/HA, phase testing/homozygosity analysis.