FIG 1.

A computational framework to create image-based patient-specific tumor molds. (A) The schematic depicts the various steps of the method, bridging from magnetic resonance imaging (MRI) scans to spatially targeted surgical biopsies. The method starts with the delineation of an MRI scan, which is then reoriented, carved out of a 3-dimensional–printed mold, and used for spatially accurate surgical biopsies. The slots of the mold guide the knife for cutting. (B) Flowchart of the different analysis steps performed by the radiology, surgery, pathology, and computational groups to ensure seamless integration between the clinical and research arms. The blue box highlights the computational steps of the pipeline. mpMRI, multiparametric MRI.