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. 2020 Jul 17;19(16):2063–2073. doi: 10.1080/15384101.2020.1792686

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Figure 7. — Regulation of Notch pathway in MM cells treated by GANT61 with different treatment times. mRNA expressions of Notch pathway-related factors (including Notch1, Jagged1, Jagged2, Hes1) after treated by 10 μmol/L GANT61 with different treatment times (0, 18, 24, 36 h) in RPMI-8226 cells (a). Protein expressions of Notch pathway-related factors (including Notch1, Jagged1, Jagged2, Hes1) after treated by 10 μmol/L GANT61 with different treatment times (0, 18, 24, 36 h) in RPMI-8226 cells (b, c). mRNA expressions of Notch pathway-related factors (including Notch1, Jagged1, Jagged2, Hes1) after treated by 10 μmol/L GANT61 with different treatment times (0, 18, 24, 36 h) in U 266 cells (d). Protein expressions of Notch pathway-related factors (including Notch1, Jagged1, Jagged2, Hes1) after treated by 10 μmol/L GANT61 with different treatment times (0, 18, 24, 36 h) in U266 cells (e, f). Comparison between two groups was determined by t-test. P value < 0.05 was considered significant. *P < 0.05; **P < 0.01; ***P < 0.001. MM, multiple myeloma.