Figure 1.

Identification and validation of genes upregulated by the p97 inhibitor CB-5083. (A) Summary of the GEO dataset evaluating whole transcriptome in HCT116 cells in response to CB-5083 (GSE73588). Independent t-test was performed to calculate Log2 ratios of CB-5083/DMSO treatments, with P < 0.0015. (B) HCT116 cells were treated with 1 μM CB-5083 for 8 h. Relative expressions of the indicated genes were analyzed by RT-PCR and quantified. p < 0.05 for differential gene expression. Data represent the mean (N = 3) and SD error.