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Rb2 inhibited pyroptosis in 3T3-L1 adipocytes. (a) mRNA levels of caspase 1, ASC, NLRP3, IL-1β and GSDMD. (b) Pro-caspase 1 and caspase 1, ratio of pro-caspase 1 to caspase 1. (c) ASC, NLRP3 and GSDMD levels in 3T3-L1 adipocytes. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01 compared with control group; #P < 0.05, ##P < 0.01 compared with TNF-α group. GSDMD is a quintessential mediator of pyroptosis
