Table 1.
Patients’ baseline information.
| Characteristics | Number or mean ± SD | Median (range) |
|---|---|---|
| No. of patients | 60 | – |
| No. of observations | 98 | – |
| Dose (mg) | – | 500 (200–1200) |
| Gender (M/F) | 44/16 | – |
| Age (year) | 60 ± 11.8 | 59 (22–88) |
| Body weight (kg) | 66.5 ± 12.1 | 66.5 (40–90) |
| Body mass index (kg/m2) | 23.0 ± 3.1 | 23.3 (15.6–28.7) |
| Height (cm) | 170 ± 6.8 | 172 (155–182) |
| Serum creatinine (µmol/L) | 66.5 ± 23.6 | 66.5 (23.6–145) |
| Total protein (g/L) | 65.9 ± 7.5 | 64.6 (7.5–81.8) |
| Albumin (g/L) | 38.9 ± 6.4 | 38.7 (25.6–53.6) |
| Globulin (g/L) | 27.1 ± 4.7 | 28.6 (4.6–36.9) |
| Alanine transaminase (U/L) | 34.3 ± 33.8 | 27.1 (5.7–214.5) |
| Aspartate transaminase (U/L) | 31.4 ± 21.0 | 26.8 (9.6–115.8) |
| CYP2C19 genotype | ||
| *1/*1 | 36 | – |
| *1/*2+*1/*3+*2/*3 | 24 | – |
| Concomitant medications | ||
| Carbamazepine | 1 | – |
| Lamotrigine | 1 | – |
| Meropenem | 1 | – |
| Imipenem | 1 | – |
M, male; F, female; SD, standard deviation.