FIGURE 1.

Epidermal growth factor receptor (EGFR) signaling is activated by fibroblast growth factor receptor 4 (FGFR4) in colon cancer cells. A, Heatmap of differentially expressed genes (DEGs) from RNA‐seq analysis of FGFR4‐transfected and vector control HT29 cells. DEGs were defined over 3 fragments per kilobase of transcript per million mapped reads (FPKM) at any group and fold change over 1.3. B, Gene ontology analysis of upregulated genes in FGFR4‐transfected cells. C, Gene Set Enrichment Analysis shown for genes related to EGFR signaling. P value and ES are shown on the graph. D, Effect of FGFR4 expression on the tyrosine phosphorylation of 49 different receptor tyrosine kinases (RTKs) was evaluated by phospho‐RTK array. The position of pEGFR is indicated with a red box