Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Clinical and genetic information for 2 heterozygous DPYS p.Gln334Arg patients with high toxicity
| Patient no. | Age | Sex | Cancer | Regimen | Side effects | Other DPYD variants | Other DPYS variants | Other UPB1 variants |
|---|---|---|---|---|---|---|---|---|
| Patient 1 | 68 | Female | Colorectal | 5FU + L‐OHP |
Vomiting Grade 1 Neutropenia Grade 3 |
p.Ile543Val het p.Arg29Cys hom |
c.‐1T>C hom | No variant |
| Patient 2 | 81 | Female | Colorectal | 5FU + L‐OHP |
Nausea Grade 2 Neutropenia Grade 3 |
p.Arg29Cys het | c.‐1T>C hom | No variant |
