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Functions, structure, and components of telomeres. A, Telomeres form t‐loops and protect chromosome ends from the DNA damage response. HR, homologous recombination; NHEJ, non‐homologous end‐joining. B, Telomeres gradually shorten according to the end‐replication problem and resection, which defines the cell replicative capacity. C, Shelterin complexes. TRF1/TRF2 and POT1 directly bind the double‐stranded and single‐stranded telomeric repeats, respectively
