Figure 2.

Telomerase‐mediated telomere synthesis and TERT promoter mutations. A, Telomerase components. Because telomerase uses RNA as a template for telomeric DNA synthesis, it is classified as a reverse transcriptase. B, The template region of TR anneals the telomeric 3′‐overhang, and telomerase repeats the strand synthesis and translocation. C, Gain‐of‐function mutations in the TERT promoter that produce ETS/TCF‐binding sites and cause TERT transcription