Figure 5.

Tankyrase as a therapeutic target for cancer. A, Structures, partners and functions of tankyrases (left). Representative tankyrase inhibitors are also shown (right). ANK, ankyrin repeats; ARC, ankyrin repeat cluster; HPS, His‐Pro‐Ser motif; SAM, sterile α motif; PARP, poly(ADP‐ribose) polymerase domain. B, Tankyrase PARylates TRF1, resulting in promotion of telomerase access and telomere elongation. Ub, ubiquitin. C, APC destruction complex induces Ub‐dependent β‐catenin degradation (upper). Tankyrase PARylates AXIN and its Ub‐dependent degradation. This causes β‐catenin accumulation and enhances target gene expression (lower)