Skip to main content
. 2020 Jul 6;111(9):3089–3099. doi: 10.1111/cas.14540

Figure 6.

Figure 6

G‐quadruplexes as therapeutic targets for cancer. A, G‐quadruplex (G4)‐forming sequences, such as telomeric repeats of various organisms, and G4 conformations. B, G4 ligands, which recognize and stabilize G4s. C, Consequences of G4 stabilization. It is postulated that G4 ligands exert anticancer effects through telomeric and non‐telomeric DNA damage induction and transcriptional/translational perturbation of cancer‐related genes