Figure 1.

Nuclear microenvironments and principles of their formation. A, The eukaryotic nucleus is highly compartmentalized and contains various membraneless organelles (nuclear bodies/structures). Their immuno‐stained or FISH images are shown. B, Multivalent interactions between proteins and nucleic acids trigger liquid‐liquid phase separation (LLPS). LLPS is reversible (left) and the resultant liquid droplet (yellow‐highlighted area) is dynamic (middle); however, its hyper self‐assembly causes irreversible solid aggregate formation (right)