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. 2020 Jul 21;111(9):3155–3163. doi: 10.1111/cas.14551

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© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Transcription regulation by membraneless structures in the nucleus. A, A super‐enhancer is a cluster of enhancers that are bound by RNA polymerase II, transcription factors, the mediator subunit MED1 and bromodomain‐containing protein 4 (BRD4). Super‐enhancers are locally concentrated and create a microenvironment for highly active transcription. B, ELEANOR RNA cloud (green) in the nucleus (blue) in a recurrent estrogen receptor‐positive breast cancer model cell (left). ELEANORS activate a large chromatin domain containing multiple breast cancer‐related genes (right)