FIGURE 3.
Tetrahedral DNA nanostructure (TDN) applications as delivery vehicles in cancer therapy. A, MUC1 aptamer‐modified TDN for selective doxorubicin (Dox) delivery to breast cancer cells. Reproduced with permission. 49 B, AS1411 aptamer‐modified TDN for selective 5‐fluorouracil (5‐FU) delivery to breast cancer cells. Reproduced with permission. 52 C, Methylene blue (MB)‐loaded TDN for in vitro and in vivo photodynamic therapy. Reproduced with permission. 59 D, Delivery of unmethylated CpG motifs by TND for the immunostimulatory effect. TLR9, Toll‐like receptor 9. Reproduced with permission. 62 E, Antisense oligonucleotide (ASO) delivery by nuclear localization signal peptide (NLS)‐modified TDN for protooncogene c‐raf silencing. Reproduced with permission 23