. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: J Allergy Clin Immunol. 2019 Sep 9;145(1):430–433. doi: 10.1016/j.jaci.2019.08.031

Table I.

Correlation of IL-6 and FeNO levels or blood eosinophil count with asthma phenotypes in SARP1–3 (partial table).

IL-6 & FeNO	LL (278)^*		LH (249)^*		HL (88)^*		HH (90)^*		Four Groups

	n	mean ± SD	n	mean ± SD	n	mean ± SD	n	mean ± SD	P value^†	P value^‡ (Adjusted)

Body mass index (BMI)	278	31 ± 6.9	249	29 ± 6.9	88	39 ± 12	90	35 ± 9.0	<0.0001	NA
Baseline FEV₁ % predicted	278	77 ± 21	249	76 ± 19	88	70 ± 21	90	70 ± 19	0.001	0.014
Blood neutrophil counts (cells/μl)	273	3974 ±1625	247	3822 ± 1562	86	5576 ± 2407	87	5379 ± 3133	<0.0001	<0.0001
Blood eosinophil counts (cells/μl)	273	201 ± 158	245	339 ± 286	85	223 ± 262	86	345 ± 270	<0.0001	<0.0001
FeNO (ppb)	278	14 ± 5.4	249	58± 41	88	15 ± 5.7	90	49 ± 35	<0.0001	<0.0001
Systemic corticosteroid use in last year (% yes)	278	28	249	27	88	45	90	50	<0.0001	0.0048
% ΔFEV₁ (corticosteroid evoked) in SARP3	145	2.6 ± 13	107	6.8 ± 16	48	1.4 ± 15	40	8.8 ± 18	0.0007	0.039

IL-6 & Blood eosinophil count	LL (344)^**		LH (216)^**		HL (113)^**		HH (65)^**		Four Groups

	n	mean ± SD	n	mean ± SD	n	mean ± SD	n	mean ± SD	P value^†	P value^‡ (Adjusted)

Body mass index (BMI)	344	30 ± 7.0	215	30 ± 7.1	113	38 ± 11	65	35 ± 9.3	<0.0001	NA
Baseline FEV₁ % predicted	344	78 ± 20	215	73 ± 19	113	71 ± 19	65	68 ± 20	<0.0001	0.0033
Blood neutrophil counts (cells/μl)	344	3818 ± 1694	216	4003 ± 1459	113	5320 ± 2800	65	5578 ± 2631	<0.0001	<0.0001
Blood eosinophil counts (cells/μl)	344	136 ± 70	216	480 ± 262	113	141 ± 80	65	524 ± 305	<0.0001	<0.0001
FeNO (ppb)	327	28 ± 29	197	47 ± 44	108	27 ± 23	63	41 ± 38	<0.0001	<0.0001
Systemic corticosteroid use in last year (% yes)	344	25	215	29	113	44	65	54	<0.0001	0.002
% ΔFEV₁ (corticosteroid evoked) in SARP3	164	3.3 ± 13	92	6.2 ± 17	55	0.4 ± 11	33	12 ± 21	0.008	0.004

LL: low IL-6 and low FeNO, LH: low IL-6 and high FeNO, HL: high IL-6 and low FeNO, HH: high IL-6 and high FeNO

^†

Kruskal-Wallis test

^‡

Generalized linear model adjusted for age, sex, BMI, and race

^**

LL: low IL-6 and low blood eosinophil count, LH: low IL-6 and high blood eosinophil count, HL: high IL-6 and low blood eosinophil count, HH: high IL-6 and high blood eosinophil count. This is a partial table for combination of IL-6 and FeNO levels or IL-6 and blood eosinophil count. Please refer to Table E9 and Table E12 for complete phenotypes tested.