Appendix Table 1.

The adjusted association between extended duration shifts and adverse safety outcomes stratified by cohort.

	Extended Duration Shifts (EDS) 2002–2007				Extended Duration Shifts (EDS) 2014–2017
	None	1–4	≥5	p-value	None	1–4	≥5	p-value
Crashes	Ref	1.20 (0.94-1.54)	1.46 (1.17-1.81)	0.002	Ref	0.98 (0.65-1.49)	2.02 (1.36-3.01)	0.03
Crashes leaving work	Ref	non-estimable			Ref	1.05 (0.56- 1.96)	1.64 (0.83- 3.23)	0.51
Near-crashes	Ref	1.48 (1.35-1.62)	1.95 (1.79-2.12)	<0.0001	Ref	1.20 (1.01-1.43)	1.45 (1.19-1.76)	0.0022
Occupational Exposures^	Ref	1.11 (0.96-1.27)	1.17 (1.03-1.33)	0.05	Ref	1.44 (1.16-1.79)	1.35 (1.02-1.79)	0.0046
Percutaneous Injuries^	Ref	0.97 (0.80-1.19)	1.07 (0.89-1.29)	0.53	Ref	1.50 (1.10-2.06)	1.29 (0.85-1.97)	0.07
Attentional Failures	Ref	1.59 (1.51-1.69)	2.21 (2.09-2.33)	<0.0001	Ref	1.37 (1.25-1.49)	1.71(1.51-1.93)	<0.0001

All models are adjusted for age, gender, BMI, specialty, and cohort. P-values are obtained from likelihood ratio tests.

^{^}Also adjusted for hours of patient care in the month.