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. 2020 Sep 3;19:323. doi: 10.1186/s12936-020-03389-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — HRP2:pLDH ratios as tool to predict infection status. a Boxplot of HRP2:pLDH ratios for individuals within 4 weeks pretreatment to 7 weeks post-treatment (n = 311). b Scatterplot of the relationship between HRP2:pLDH vs. HRP2. c Density plot of HRP2:pLDH ratios for individuals with active vs. cleared P. falciparum infection and HRP2 > 100 pg/mL. With a cutoff of 8.99 HRP2:pLDH ratio, cleared infection is predicted with sensitivity = 88.9%, specificity = 89.7%, and AUC = 0.92. d Density plot of HRP2:pLDH ratios for individuals with active vs. cleared infection and HRP2 ≤ 100 pg/mL. With a cutoff of 0.49 HRP2/pLDH ratio, cleared infection is predicted with sensitivity = 64.1%, specificity = 85.7%, and AUC = 0.77. AUC, area under the curve; HRP2, histidine rich protein 2; pLDH, Plasmodium lactate dehydrogenase