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. 2020 Aug 20;10:1457. doi: 10.3389/fonc.2020.01457

Figure 4.

Figure 4

Analysis of mutation signatures enriched in ESCC from smokers, chewers and tobacco non-users. (A) Mutation signatures associated with ESCC from smokers, chewers and tobacco non-users. Height of the bar represents contribution of the base substitution across different trinucleotide contexts. (B) Mutation load of C > A transversions and C > T transitions in smokers, chewers and tobacco non-users. (C) Results of mutation signature decomposition in ESCC samples from chewers, smokers and tobacco non-users. (Red) Chewers, (Gray) Non-users, and (Orange) Smokers.