Table 4.

Multivariable regression of severe neonatal morbidity by timing of antenatal corticosteroid administration

	Severe neonatal morbidity* adjusted odds ratio (95% confidence interval)	p-value
Timing of antenatal corticosteroid administration
< 2 days before delivery	0.80 (0.59–1.07)	0.135
2 to <7 days before delivery	1.0 (referent)	-
7 to <14 days before delivery	1.15 (0.83–1.58)	0.404
≥ 14 days before delivery	1.57 (1.12–2.19)	0.009
Gestational age at delivery, per completed week	0.55 (0.53–0.58)	<0.001
Male gender	1.31 (1.04–1.65)	0.022
Nulliparous mother	1.18 (0.93–1.49)	0.185
Delivery by cesarean section	1.23 (0.97–1.56)	0.092

Other factors considered in initial models but removed due to p>0.20 include preterm prelabor rupture of membranes, receipt of magnesium sulfate prior to delivery (for any indication), maternal smoking during pregnancy, black race, and suspected clinical chorioamnionitis.

^*Composite included death, severe intraventricular hemorrhage grade III or IV, periventricular leukomalacia, bronchopulmonary dysplasia, or necrotizing enterocolitis