Table 1:
MicroRNAs (miRNAs) That Affect Invasion in Head and Neck Squamous Cell Carcinoma
| miRNA | Effect on invasion | Target | Function | Reference |
|---|---|---|---|---|
| hsa-miR-1 | Reduction | TAGLN2 | Cytoskeleton | 178 |
| hsa-miR-107 | Reduction | PRKCE | Signaling | 174 |
| hsa-miR-29a,b,c | Reduction | LAMC2, ITGA6, MMP2, SP1 | Adhesion, Proteolysis, Gene expression | 148,176,188 |
| hsa-miR-99a | Reduction | IGF1R | Signaling | 171 |
| hsa-miR-126 | Reduction | EGFL7, VEGF, FGF2 | Signaling | 169 |
| hsa-miR-133a | Reduction | CAV1, MSN, ARPC5 | Cytoskeleton | 179,180,302 |
| hsa-miR-138 | Reduction | RHOC, ROCK2, VIM, ZEB2, EZH2 |
Cytoskeleton EMT |
212,213,184,185 |
| hsa-miR-140–5p | Reduction | ADAM10 | Proteolysis | 177 |
| hsa-miR-181a | Reduction | TWIST1 | EMT | 187 |
| hsa-miR-218 | Reduction | LAMB3 | Adhesion | 175 |
| hsa-miR-363 | Reduction | PDPN | Cytoskeleton | 181 |
| hsa-miR-375 | Reduction | MTDH | Gene expression | 189–193 |
| hsa-miR-491–5p | Reduction | GIT1 | Adhesion | 303 |
| hsa-miR-639 | Reduction | FOXC1 | Gene expression, EMT | 194 |
| hsa-miR-21 | Increase | DKK2, PDCD4 | Signaling, Protein Synthesis | 97,170,195 |
| hsa-miR-134 | Increase | WWOX | Cell death | 304 |
| hsa-miR-155 | Increase | SOCS1 | Signaling | 173 |
| hsa-miR-193b | Increase | NF1 | Signaling | 172 |
| hsa-miR-504 | Increase | FOXP1 | Gene expression | 194 |
| hsa-miR-222 | Mixed | BBC3, SOD2 | Cell death/ROS | 196,197 |
Abbreviations: EMT – epithelial to mesenchymal transition, ROS – reactive oxygen species