TABLE 3.
Proportion of individuals and median time to recurrent serious infection and death, and hazard ratio for recurrent serious infection comparing individuals with sarcoidosis to the general population
| Sarcoidosis | General population | |||
| Subjects | Years to event | Subjects | Years to event | |
| Subjects | 8737 | 86 376 | ||
| Serious infection | ||||
| 0 | 7841 (89.7) | 82 493 (95.5) | ||
| 1 | 1224 (14.0) | 1.9 (0.6–4.1) | 6158 (7.1) | 2.9 (1.3–5.2) |
| 2 | 489 (5.6) | 2.9 (1.3–5.0) | 1536 (1.8) | 4.2 (2.3–6.2) |
| 3 | 248 (2.8) | 3.8 (1.6–5.5) | 696 (0.8) | 4.9 (2.7–6.4) |
| 4 | 150 (1.7) | 4.4 (2.6–5.7) | 305 (0.4) | 5.4 (3.2–6.9) |
| 5 | 84 (1.0) | 5.4 (3.3–6.8) | 150 (0.2) | 5.6 (2.9–7.5) |
| 6 | 105 (1.2) | 6.2 (4.2–7.4) | 224 (0.3) | 5.2 (3.6–7.5) |
| Death | ||||
| Overall | 539 (5.3) | 2.7 (1.1–5.4) | 3010 (3.3) | 3.6 (1.8–5.8) |
| Due to serious infection# | 109 (1.2) | 499 (0.6) | ||
| Hazard ratio for recurrent serious infection¶ (95% CI) | ||||
| Crude | 3.30 (2.99–3.64) | 1.00 (referent) | ||
| Adjusted | 2.79 (2.51–3.10) | 1.00 (referent) | ||
Data are presented as n, n (%) or median (interquartile range), unless otherwise stated. #: serious infection coded as underlying or contributing cause of death on the death certificate (data from the Cause of Death Register); ¶: within-individual hazard ratio estimated from a Cox proportional hazards model with a γ-frailty term (per individual; a shared frailty model). Adjusted hazard ratio estimated using inverse probability of sarcoidosis weights.