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. 2020 Jul 1;133(15):1868–1877. doi: 10.1097/CM9.0000000000000908

Figure 1.

Figure 1

Circular RNA synthesis. Most pre-mRNA remove introns and splice the remaining exon sequences to form mature linear mRNA. In circRNA, the upstream 5′ cleavage site and the downstream 3′ cleavage site are linked by a covalent bond to form a circular transcript. circRNA: Circular RNA; pre-mRNA: Precursor mRNA.