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. 2020 Jul 1;133(15):1868–1877. doi: 10.1097/CM9.0000000000000908

Figure 2.

Figure 2

Function of circular RNA. (A) Regulation of gene expression: circRNA binds to snRNA in the U1 nucleus, and then binds to the promoter region of the parent gene together with RNA polymerase II (Pol II) to regulate its own expression; (B) miRNA sponge effect of circRNA: circRNAs have many miRNA binding sites, which can bind to their corresponding miRNAs and act as ceRNAs; (C) interact with RNA binding proteins: circRNA can bind to RBP to form an RNA-protein complex; (D) translation role of circRNA: circRNAs contain an IRES, the eukaryotic ribosomal 40S small subunit can enter the internal ribosome entry site of these circRNAs through this site, thereby guiding protein synthesis. ceRNA: Competing endogenous RNA; circRNA: Circular RNA; IRES: Internal ribosome entry site; miRNA: MicroRNA; RBP: RNA binding protein; snRNA: Small nuclear RNA.