Table 1.

Results of the in vitro growth inhibition (GI %) of tested compounds against human cancer cell lines in the single-dose assay^a.

Cell type	Cell line	GI (%) (10–5 M)a
	Compound	11a	11b	11d	11e	11f	11i	11j	11k	14a	15a	15j
Leukaemia	CCRF-CEM	83	65	24	10	20	0	0	0	0	100b,p	100b,i′
	K-562	89	86	23	1	11	0	0	0	2	100b,q	100b,j′
	SR	76	84	32	30	30	0	0	14	5	100b,r	100b,k′
	HL-60(TB)	100b,c	100b,l	30	35	28	0	0	0	2	67	75
	MOLT-4	76	69	34	0	0	0	0	0	3	100b,s	89
	RPMI-8226	77	72	10	43	13	0	0	27	15	100b,t	77
Non-small cell lung cancer	A549/ATCC	74	64	11	20	11	0	14	53	0	68	68
	HOP-62	72	70	10	10	11	13	4	47	4	5	12
	NCI-H460	86	85	0	3	0	0	12	82	0	100b,u	96
	NCI-H522	74	59	25	21	19	34	7	100b,o	13	100b,v	29
Colon cancer	COLO205	100b,d	86	0	0	0	0	0	35	0	56	57
	HCT-116	81	88	19	24	3	11	0	0	3	100b,w	95
	HCT-15	71	74	17	1	0	0	0	17	3	17	25
	HT-29	99	90	23	8	12	0	0	23	0	100b,x	100b,l′
	SW-620	70	78	7	0	0	0	0	41	4	100b,z	100b,m′
	KM12	75	76	2	0	2	0	0	23	0	55	36
CNS cancer	SF-295	79	73	3	0	0	9	0	31	0	6	0
	SF-539	100b,e	55	3	6	0	12	11	70	0	70	10
	SNB-75	67	79	2	11	9	17	15	76	38	24	7
	U251	78	61	10	7	5	26	14	78	0	100b,a′	87
	SF-268	44	53	11	4	0	3	7	75	11	100b,b′	21
Melanoma	LOX IMVI	53	61	8	1	3	0	0	15	6	100b,c′	87
	M14	100b,f	96	0	0	0	5	0	0	0	45	43
	MDA-MB-435	100b,g	100b,m	0	0	0	0	0	29	11	31	24
	UACC-62	50	69	11	1	2	8	1	16	6	13	0
	SK-MEL-5	62	73	7	17	3	0	7	63	4	18	2
Ovarian cancer	OVCAR-3	100b,h	100b,n	0	0	0	0	0	21	0	18	63
	NCI/ADR-RES	89	88	8	1	0	0	0	34	5	6	11
	SK-OV-3	78	64	18	13	19	6	0	94	0	0	9
	OVCAR-8	67	58	12	9	6	0	9	63	8	93	23
	OVCAR-4	32	28	8	4	0	–	–	–	0	100b,d′	70
Renal cancer	A498	100b,i	71	2	14	0	0	6	58	0	20	26
	RXF393	100b,j	50	3	5	0	9	6	36	0	34	27
	ACHN	41	51	0	0	0	19	10	70	8	9	4
	786-0	65	64	0	10	0	9	0	0	–	100b,e′	91
	TK10	51	44	0	10	0	0	0	45	0	87	0
Breast cancer	MCF7	76	78	15	0	0	5	10	17	6	100b,f′	99
	MDA-MB-468	100b,k	70	3	30	9	10	6	25	0	57	29
	T-47D	53	51	16	16	0	9	20	77	0	50	17
	MDA-MB-231/ATCC	62	44	18	30	11	10	6	42	12	100b,g′	29
	BT-549	60	64	0	9	0	13	0	4	0	100b,h′	18
Prostate cancer	PC-3	88	60	17	15	12	2	9	13	2	46	49
	DU-145	75	46	0	0	0	0	0	35	0	55	70

^aData obtained from NCI’s in vitro 60 cell one dose screening at 10⁻⁵ M concentration; compounds 11l and 14d were also tested, but no GI was exhibited on the tested cell lines (results are not shown).

^bCytotoxic effect; cell growth percent: ^c-25; ^d-32; ^e-7; ^f -22; ^g-42; ^h-6; ⁱ-1; ^j-0.4; ^k-7; ^l-14; ^m-5; ⁿ-5; ^o-4; ^p-15; ^q-45; ^r-16; ^s-9; ^t-22; ^u-10; ^v-21; ^w-61; ^x-10; ^z-65; ^a′-74, ^b′-14, ^c′-44; ^d′-33; ^e′-82; ^f′-29; ^g′-23; ^h′-6; ^i′-3; ^j′-53; ^k′-27; ^l′-10; ^m′-30.

The best values in terms of growth inhibition are highlighted in bold.