Table 1.
Description of the study population and outcome by prescribed antibiotic.
| Antibiotic | Pivmecillinam | Nitrofurantoin | Trimethoprim | SXTa | Ciprofloxacin | Total |
|---|---|---|---|---|---|---|
| n = 5234 | n = 3223 | n = 920 | n = 791 | n = 10956 | n = 21 124 | |
| Age, years, median (IQR) | 64 (49–72) | 65 (49–72) | 66 (53–73) | 66 (56–72) | 65 (53–72) | 65 (51–72) |
| Level of care, index | ||||||
| Primary health care n (%) | 4815 (92.0) | 3014 (93.5) | 756 (82.2) | 406 (51.3) | 8188 (74.7) | 17179 (81.3) |
| Hospital care n (%) | 419 (8.0) | 209 (6.5) | 164 (17.8) | 385 (48.7) | 2768 (25.3) | 3945 (18.7) |
| Measurements | ||||||
| Median temperatureb Celsius (IQR) | 36.9 (36.5–37.2) | 36.9 (36.6–37.2) | 36.8 (36.4–37.2) | 37.5 (36.8–38.3) | 37.0 (36.6–37.6) | 37.2 (36.7–37.9) |
| CRP, mg/Lc median, (IQR) | 7.0 (5.0–26.0) | 7 (5–26.0) | 11.0 (5.0–36.2) | 41.0 (14.0–96.0) | 40 (8.0–96.0) | 24.0 (5–75) |
| Nitrite-positivedn(%) | 796 (30) | 400 (27) | 111 (27) | 130 (42) | 1917 (39) | 3354 (34) |
| Leukocytes posistiveen(%) | 2310 (70) | 1242 (67) | 395 (76) | 342 (78) | 5124 (77) | 9413 (74) |
| Urine culture analysed n (%) | 2701 (52) | 1613 (50) | 512 (56) | 503 (64) | 6326 (58) | 11 655 (55) |
| Duration of therapy | ||||||
| 0-9 days n (%) |
4722 (90.4) | 2839 (88.2) | 677 (73.8) | 357 (45.5) | 5251 (48.0) | 15073 (65.5) |
| 10 days or more, n (%) | 501 (9.6) | 380 (11.8) | 240 (26.2) | 428 (54.1) | 5679 (51.8) | 7834 (34.1) |
| Median duration of therapy days (IQR) | 7 (7–7) | 5 (5–7) | 7 (5–10) | 10 (7–10) | 10 (7–10) | 7 (7–10) |
| Outcome | ||||||
| Therapy failure n (%) | 63 (1.2) | 40 (1.2) | 11 (1.2) | 11 (1.2) | 69 (0.6) | 192 (0.9) |
| Recurrence n (%) | 496 (9.5) | 283 (8.8) | 61 (6.6) | 61 (6.6) | 384 (3.5) | 1277(6.0) |
| Complication n (%) | 25 (0.5) | 20 (0.6) | 4 (0.4) | 4 (0.4) | 61 (0.6) | 121 (0.6) |
a
SXT: Trimethoprim/sulfamethoxazole.
b
Missing cases for temperature, 13,242 (62.7%) of all index patients.
c
CRP (C-reactive protein), missing cases 12,345 (58.4%).
d
Measured by dipstick test in urine, missing cases 11,118 (53%).
e
Measured by dipstick test in urine, missing cases 9413 (46%).