Figure 2.
(A) Proposed tethering position on olaparib based upon the co-crystal structure of olaparib in complex with PARP-1 (PDB ID: 4TKG). (B) The SAR of olaparib. (C) Design of PARP-1 degraders based upon the PROTAC concept.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.