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. 2020 Aug 11;35(1):1606–1615. doi: 10.1080/14756366.2020.1804382

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (A) Dose-response curves of compound 1–3 and olaparib for PARP-1 inhibition. (B) Dose-dependent western blot analysis of PARP-1 and GAPDH after treatment of SW620 cells with six different concentrations of compounds 1, 2, 3, olaparib and lenalidomide for 24 h before harvesting. (C) Time-dependent experiment in SW620 cells after treatment with 10 μM compound 2 at the desired time points. (D) Dose-response curves of compound 2 and olaparib in incubation with cancer cell lines (mean ± SD, n = 3).