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Cytotoxic impact for pyridazines 11l and 11m against non-tumorigenic MCF-10A human breast cell line, as well as mean tumour selectivity index (S. I.) (MCF-10A/T-47D and MDA-MB-231).
| Comp. | IC50 (µM) |
Mean tumour selectivity | ||
|---|---|---|---|---|
| MCF-10A | T-47D | MDA-MB-231 | ||
| 11l | 19.63 ± 0.38 | 1.57 ± 0.05 | 1.30 ± 0.04 | 13.7 |
| 11m | 11.44 ± 0.22 | 0.43 ± 0.01 | 0.99 ± 0.03 | 16.1 |
