Table 6.

The in silico predicted ADME for pyridazines 11e, 11h, 11l, and 11m.

Cpd.	BBB	GIA	P-gP substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
11e	No	Low	Yes	No	No	No	Yes	Yes
11h	No	High	No	No	Yes	No	No	Yes
11l	Yes	High	Yes	Yes	No	No	Yes	No
11m	Yes	High	Yes	Yes	No	No	No	No

GIA: gastrointestinal absorption; BBB: Blood Brain Barrier; PgP: P-glyco protein transporter.