Table 2.

Pharmacokinetic parameters for 10 mg oxycodone hydrochloride (9.0 mg free base) after coronary artery by-pass surgery in the different treatment groups.

Group	Study day	n	AUC0–24a	Corrected AUC0–24b	Cmaxa	tmax	t1/2
			(ng·min/mL)	(ng·min/mL)	(ng/mL)	(min)	(min)
1 (CECC)	Preoperative	6	4250 [3590–6570]	4250 [3590–6570]	6.4 [5.7–10.0]	180 [120–270]	387 [299–481]
	POD1	6	3650 [2760-4550]	3620 [2760–4490]	6.9 [4.2–9.8]	630 [270–1420]	–
	POD3	6	7060 [6450-7270]§§	6130 [5610–6800]§	10.6 [7.7–11.8]*,§	120 [60–720]	437 [376–475] (n = 5)
2 (CECC)	Preoperative	6	3830 [3560-6070]	3830 [3560–6070]	6.0 [5.1–9.4]	180 [30–180]	394 [313–496]
	POD2	6	5600 [3790-7250]	4960 [3140–6070]	8.8 [7.6–10.3]	180 [120–360]	346 [286–968]
	POD4	6	6220 [5270-8610]*	5500 [4920–6990]	10.3 [7.8–12.7]*	180 [120–270]	330 [293–348]
3 (OPCAB)	Preoperative	6	4560 [4280-6480]	4560 [4280–6480]	7.2 [5.7–9.3]	225 [120–360]	417 [378–531]
	POD1	6	3740 [1390-5400]	3690 [1360–5320]	5.6 [1.7–10.2]	1020 [720–1410]	–
	POD3	6	8000 [5620-9520]§§	5990 [3990–8330]§	10.1 [8.1–13.2]§	315 [180–720]	462 [311–463] (n = 5)
4 (OPCAB)	Preoperative	6	3720 [1930-4870]	3720 [1930–4870]	6.5 [4.0–7.1]	150 [60–270]	309 [244–497]
	POD2	6	4570 [3370-8570]	4030 [2100–5990]	8.4 [3.6–12.7]	230 [120–720]	333 [263–394] (n = 4)
	POD4	5	4640 [2190-8170]	4410 [2040–7150]	7.3 [5.0–12.8]	270 [120–540]	374 [195–472]

Data are presented as the median [minimum–maximum] (n for t_1/2 if different from the group size).

^aBased on the observed concentrations, ^bthe carry-over from the previous doses were subtracted as described in Materials and methods. Abbreviations: POD, postoperative day; CECC, conventional extracorporeal circulation; OPCAB, off-pump coronary artery bypass surgery. Significances: *p < .05 vs. Preoperative day; ^§p < .05 vs. POD1; ^§§p < .01 vs. POD1.