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(A) Synthesis route for A series. Reagents and conditions. a: CH2Cl2, Et3N; b: NaH, DMF (B) Synthesis route for B series. Reagents and conditions. a: ClSO3H; b: pyrrolidine or 16, Et3N, DMF, c: acetic acid; d: 9 or propargyl bromide, NaH, DMF, 0 ˚C; e: p-toluenesulfonyl chloride, pyridine; f: phenol, NaH, THF; g: TFA, CH2Cl2.
