Table 1.

Structures of compounds 11a–k, 19a–k, and 20a–k displaying inhibitory effects on caspase-3 and -7.

^aIC₅₀ values are expressed as Mean ± SD of three experiments. ^bN.D. = Not determined. ^cIC₅₀ amount for Ac-DEVD-CHO is 0.016 ± 0.002 μM. ^dThe values given in bracket are percentage inhibition. ^dSelectivity Index (SI) was calculated as IC₅₀ caspase-7/IC₅₀ caspase-3.