Table 2.

CST inhibitory activity of galactocerebroside analogues

Compound	Structure	Ki ± SEM (µM) versus galactosylceramide (% inhibition at 100 µM)	Ki ± SEM (µM) versus KRN7000 (% inhibition at 100 µM)
β-Glycosides
9 Glucosylceramide	R = saturated or unsaturated alkyl or hydroxyalkyl residue	(9%)	(−5%)
α-Glycosides
16		127 ± 12	159 ± 55
20		(4%)	(1%)
21		(4%)	(−30%)
22		(−7%)	(1%)