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Skin penetration and intradermal dissolution of the blank DMNP. (A) Histological skin sections were prepared after insertion of DMNP to show skin penetration, scale bar, 200 μm. (B) The morphology of DMNP taken out from the rat skin at different time intervals after penetration, scale bar, 500 μm. (C) Images of DMNP-treated rats dorsal skin (C1, at different time intervals; C2, after 24 h DMNP-treated), scale, 5 mm.
