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. 2020 Aug 28;9(1):1810489. doi: 10.1080/2162402X.2020.1810489

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Phenotyping intratumoral CXCR5⁺CD8⁺ T cells in MIBC patients.

(a) Comparison of immune checkpoints (PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT) expression on CXCR5⁺CD8⁺ T cell vs. CXCR5⁻ CD8⁺ T cell in MIBC. (b) Comparison of effector cytokines (IFN-γ, GZMB, TNF-α and CD107a) expression on CXCR5⁺CD8⁺ T cell vs. CXCR5⁻ CD8⁺ T cell in MIBC. (c) Comparison of IL-17A expression on CXCR5⁺CD8⁺ T cell vs. CXCR5⁻ CD8⁺ T cell in MIBC. (d) Comparison of TCF-1, CCR7, CD62L and Ki-67 expression on CXCR5⁺CD8⁺ T cell vs. CXCR5⁻ CD8⁺ T cell in MIBC. Data was analyzed by Pearson correlation test and Student t test. *P < .05, **P < .01, ***P< .001, ****P < .0001.