Table 1.
Patient, tumor, and treatment characteristics of evaluable patients, by study group
| Minocycline (n = 20) | Placebo (n = 20) | P | |
|---|---|---|---|
| Age | 56.15 (SD 5.8) | 55.6 (SD 10.2) | 0.58 |
| Educational level | 0.63 | ||
| 12th grade and below | 3 | 2 | |
| Beyond 12th grade | 17 | 18 | |
| Race | 0.31 | ||
| White non-Hispanic | 19 | 20 | |
| Hispanic | 1 | 0 | |
| Sex (Male) | 14 | 17 | 0.45 |
| Feeding tube (yes) | 2 | 5 | 0.21 |
| Diagnosis | 0.76 | ||
| Tonsil | 10 | 8 | |
| Base of tongue | 5 | 7 | |
| Overlap/unknown | 5 | 5 | |
| ECOG performance status | 0.05 | ||
| Grade 0 | 16 | 10 | |
| Grade 1 | 4 | 10 | |
| Stage | 0.61 | ||
| I | 1 | 1 | |
| II | 2 | 4 | |
| III | 3 | 5 | |
| IV | 14 | 10 | |
| T category | 0.18 | ||
| 0 | 4 | 4 | |
| I | 13 | 7 | |
| 2 | 2 | 7 | |
| X | 1 | 2 | |
| N category | 0.43 | ||
| 0 | 2 | 2 | |
| 1 | 2 | 5 | |
| 2a | 5 | 3 | |
| 2b | 8 | 7 | |
| 2c | 1 | 3 | |
| X | 2 | 0 | |
| RT dose | 66.6 | 67.3 | 0.56 |
| Induction chemotherapy (yes) | 4 | 7 | 0.29 |
| Neck RT location | 0.74 | ||
| Ipsilateral | 14 | 13 | |
| Bilateral | 6 | 7 | |
| Charlson comorbidity index | 0.10 (SD 0.31) | 0.15 (SD 0.37) | 0.65 |
ECOG Eastern Cooperative Oncology Group performance status, RT radiation therapy, SD standard deviation