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. 2020 Jan 14;2(3):acmi000088. doi: 10.1099/acmi.0.000088

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© 2020 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License.

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Fig. 3. — The most enriched pathways of the hub genes based on gene ontology analysis using enricher databases. (a) WikiPathway 2019; according to this server, most hub genes are involved in apoptosis, oxidative stress, PI3K/Akt-mTOR, pro-inflammatory interleukins as well as the cell survival signalling pathway. (b) Biological process; this indicates that the processed hub genes are from the dysregulating apoptosis, oxidative stress, FasL and p53 signalling pathways that play key roles in death, cell survival and central nervous system (CNS) neurodegeneration.