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. 2020 Sep 3;15(9):e0238238. doi: 10.1371/journal.pone.0238238

Fig 1. The chemical structures of TMZ and NEO212.

Fig 1

TMZ was conjugated with perillyl alcohol via a carbamate bridge to generate NEO212. The derivatization of TMZ with perillyl alcohol creates a new chemical entity with new physicochemical properties but presumably retains the same alkylating properties of TMZ. This is because NEO212 breaks down to release intact TMZ and therefore the same methyl group (in red) in NEO212 as in TMZ will eventually be donated by NEO212 to DNA nucleobases via the release of the same highly reactive methanediazonium chemical species.