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. 2020 Sep 3;15(9):e0238238. doi: 10.1371/journal.pone.0238238

Fig 10. NEO212 is a robust radiosensitizer of TMZ-resistant GB cell lines.

Fig 10

Fold sensitization values were determined from qICC and FACS datasets. Values >1 indicate synergistic effects (i.e., radiosensitization). Values equal to 1 indicate additive effects and values <1 indicate antagonistic effects. Panel A shows the tabulated fold sensitization data for TMZ and NEO212 either as monotherapies or in combination with Olaparib (Ola). While TMZ cannot sensitize MGMT-proficient or MMR-deficient cell lines to ionizing radiation (values in blue), NEO212 appears to consistently do so (values in red). The blue (TMZ) and red (NEO212) values for TMZ-resistant cell lines are graphed in Panels B and C. A low concentration of Olaparib (i.e., 10 nM) added to either TMZ or NEO212 further improve the radiosensitization profiles of both drugs. All values were found statistically significant (*signifies a p<0.01 while **signifies a p<0.001 as determined by ANOVA with Tukey post-hoc testing).