Fig 5. Increased fluorescence intensity (F.I) of myelin after the combination treatment with erythropoietin and dexamethasone for mouse sciatic nerve crush injury.

(A) The numbers of axons at different distances in the erythropoietin and erythropoietin + dexamethasone treatment groups were larger those that in the control (saline treatment) groups, but these differences were not significant. (B) The F.I of myelin at different distances in the pharmacological treatment groups was larger than that in the saline-treated group. These findings were significant at a distance of 500 μm for all the pharmacological treatment groups and at 1000 and 1500 μm for the erythropoietin+ dexamethasone treatment group. (n = 4 / group; *P < 0.1, **P < 0.05 vs. saline-treated group; F.I, fluorescence intensity; saline, mice treated with saline; EPO, mice treated with erythropoietin; Dexa, mice treated with dexamethasone; EPO+Dexa, mice treated with erythropoietin and dexamethasone).