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. 2020 Sep 3;15(9):e0236336. doi: 10.1371/journal.pone.0236336

Fig 1. Biomarker expression levels in serum of Holstein Friesian cattle showing different types of histological lesions consistent with PTB in their intestinal tissues (focal (n = 55), multifocal (n = 18), and diffuse (n = 15)) and in non-infected control animals (n = 67).

Fig 1

The number of animals with focal, multifocal, diffuse or with any type of lesions represented in the plot for the ABCA13-based ELISA was 53, 16, 14 and 83, respectively. Biomarkers were detected and quantified in bovine serum by specific ELISAs supplied by MyBioSource, San Diego, CA, USA. FAM84A, bovine family with sequence similarity 84 member A; DES, bovine desmin; ABCA13, bovine ATP binding cassette subfamily A member 13; MMP8, bovine matrix metallopeptidase 8; SPARC, bovine secreted protein acidic and cysteine rich; IDEXX ELISA. The data are represented as scatter plots with each dot representing a single animal. The mean of each histopathological group is represented by a gross black point and the standard deviation by a vertical line. The asterisks indicate if the differences between each histopathological group and the control are or not significant (*, p<0.05; **, p<0.01; ***, p<0.001).