Table 1. Differential expression of host biomarker genes selected after RNA-Seq analysis of peripheral blood of Holstein cattle with focal and diffuse histological lesions vs. control animals without detected lesions.
| Biomarker ID | Gene ID | Focal vs. Control | Diffuse vs. Control | ||
|---|---|---|---|---|---|
| Mean Log2 fold change | P-value | Mean log2 fold change | P-value | ||
| MMP8 | XLOC_010350 | 1.89 | 0.00035 | ||
| ABCA13 | XLOC_033714 | 3.74 | 0.00005 | ||
| FAM84A | XLOC_005071 | 2.15 | 0.00005 | ||
| SPARC | XLOC_040915 | 2.21 | 0.00065 | ||
| DES | XLOC_019473 | 3.75 | 0.00030 | ||
The mean Log2 fold change, is a measurement (ratio) of differential gene expression between two compared groups expressed as a logarithm; MMP8, bovine matrix metallopeptidase 8; ABCA13, bovine ATP binding cassette subfamily A member 13; FAM84A, bovine family with sequence similarity 84 member A; SPARC, bovine secreted protein acidic and cysteine rich; DES. bovine desmin.