Table 1.
Comparison of Patients with OIAI and Without OIAI
| All Patients | Patients with Diagnosis of OIAI | Patients without Diagnosis of OIAI | P Value | |
|---|---|---|---|---|
| N | 102 | 9 | 93 | |
| Women, n (%) | 66 (65) | 7 (77.8) | 59 (63.4) | 0.39 |
| Caucasian, n (%) | 93 (91) | 8 (89) | 85 (91.4) | 0.79 |
| Age, years median (range) | 54 (24-83) | 54 (24-83) | 53 (47-75) | 0.58 |
| BMI, kg/m2 median (range) | 28.6 (17.4-46) | 29.9 (33.5-45.6) | 28.6 (17.4-46) | 0.66 |
| MME, mg median (range) | 60 (3-840) | 140 (20-392) | 57 (3-840) | 0.06 |
| Duration of opioid use, months median (range) | 60 (3-360) | 96 (6-204) | 60 (3-360) | 0.19 |
| Cumulative opioid exposure, mg*months median (range) | 3600 (30-156720) | 13440 (120-36000) | 3120 (30-156720) | 0.03 |
| Cortisol, mcg/dL median (range) | 13 (1-37) | 5.4 (1-9.9) | 14 (2.4-37) | <0.0001 |
| ACTH, pg/mL median (range) | 19 (5-97) | 11 (5-15) | 21 (7-97) | 0.0002 |
| DHEAS, mcg/dL median (range) | 60 (<15-379) | 17.3 (<15-24) | 64 (<15-379) | <0.0001 |
Abbreviations: DHEAS, dehydroepiandrosterone sulfate; MME, morphine equivalent; OIAI, opioid-induced adrenal insufficiency.