Table 6.
Comparison of verbal autopsy open response terms and question endorsements related to the major causes of child mortality between azithromycin- and placebo-treated communities
| VA item | Intention-to-treat analysis | Per protocol analysis | ||||
|---|---|---|---|---|---|---|
| Total deaths | Number of interviews in which item endorsed (%) | P-value* | Total deaths | Number of interviews in which item endorsed (%) | P-value* | |
| Open response term “malaria” | ||||||
| Placebo | 597 | 273 (45.7) | 461 | 220 (47.7) | ||
| Azithromycin | 534 | 262 (49.1) | 0.26 | 431 | 217 (50.3) | 0.44 |
| Open response term “pneumonia” | ||||||
| Placebo | 597 | 49 (8.2) | 461 | 40 (8.7) | ||
| Azithromycin | 534 | 27 (5.1) | 0.03 | 431 | 22 (5.1) | 0.04 |
| Open response term “diarrhea” | ||||||
| Placebo | 597 | 131 (21.9) | 461 | 96 (20.8) | ||
| Azithromycin | 534 | 90 (16.9) | 0.03 | 431 | 75 (17.4) | 0.19 |
| Maternal test positive for HIV | ||||||
| Placebo | 597 | 45 (7.5) | 461 | 35 (7.6) | ||
| Azithromycin | 534 | 41 (7.7) | 0.93 | 431 | 37 (8.6) | 0.59 |
| Frequent loose/liquid stool continuing until death | ||||||
| Placebo | 597 | 222 (37.2) | 461 | 170 (36.9) | ||
| Azithromycin | 534 | 161 (30.1) | 0.01 | 431 | 133 (30.9) | 0.06 |
| Very severe cough | ||||||
| Placebo | 597 | 56 (9.4) | 461 | 44 (9.5) | ||
| Azithromycin | 534 | 48 (9.0) | 0.82 | 431 | 38 (8.8) | 0.70 |
| Severe fever | ||||||
| Placebo | 597 | 282 (47.2) | 461 | 225 (48.8) | ||
| Azithromycin | 534 | 261 (48.9) | 0.58 | 431 | 202 (46.9) | 0.56 |
*
From test of proportions.